Hypertension, antihypertensive treatment and cancer incidence and mortality: A pooled collaborative analysis of 12 Australian and New Zealand cohorts
dc.contributor.author | Harding, Jessica | |
dc.contributor.author | Sooriyakumaran, Manoshayini | |
dc.contributor.author | Adams, Robert | |
dc.contributor.author | Balkau, Beverley | |
dc.contributor.author | Brennan-Olsen, Sharon | |
dc.contributor.author | Briffa, Tom G | |
dc.contributor.author | Davis, Timothy | |
dc.contributor.author | Dobson, Annette | |
dc.contributor.author | Giles, Graham G | |
dc.contributor.author | Grant, Janet | |
dc.contributor.author | Huxley, Rachel | |
dc.contributor.author | Knuiman, Matthew | |
dc.contributor.author | Luszcz, Mary A | |
dc.contributor.author | Mitchell, Paul | |
dc.contributor.author | Pasco, Julie A. | |
dc.contributor.author | Reid, Christopher | |
dc.contributor.author | Simmons, David | |
dc.contributor.author | Simons, Leon | |
dc.contributor.author | Taylor, Anne | |
dc.contributor.author | Tonkin, Andrew | |
dc.contributor.author | Woodward, Mark | |
dc.contributor.author | Shaw, Jonathan | |
dc.contributor.author | Magliano, Dianna | |
dc.contributor.author | Anstey, Kaarin | |
dc.date.accessioned | 2016-06-14T23:20:42Z | |
dc.date.issued | 2016 | |
dc.date.updated | 2016-06-14T08:51:40Z | |
dc.description.abstract | Background: Observational studies examining associations between hypertension and cancer are inconsistent. We explored the association of hypertension, graded hypertension and antihypertensive treatment with cancer incidence and mortality. Method: Eighty-six thousand five hundred and ninety-three participants from the Australian and New Zealand Diabetes and Cancer Collaboration were linked to the National Death Index and Australian Cancer Database. Cox proportional hazards models estimated hazard ratios and 95% confidence intervals (95% CI) for the association of treated and untreated hypertension with cancer incidence and mortality. Results: Over a median follow-up of 15.1 years, 12 070 incident and 4350 fatal cancers were identified. Untreated and treated hypertension, compared with normotension, were associated with an increased risk for cancer incidence [hazard ratio 1.06, 95% CI (1.00–1.11) and 1.09 (1.02– 1.16) respectively], and cancer mortality (1.07, 0.98–1.18) and (1.15, 1.03–1.28), respectively. When compared with untreated hypertension, treated hypertension did not have a significantly greater risk for cancer incidence (1.03, 0.97–1.10) or mortality (1.07, 0.97–1.19). A significant dose–response relationship was observed between graded hypertension and cancer incidence and mortality; Ptrend¼ 0.053 and Ptrend¼ 0.001, respectively. When stratified by treatment status, these relationships remained significant in untreated, but not in treated, hypertension. Conclusion: Hypertension, both treated and untreated, is associated with a modest increased risk for cancer incidence and mortality. Similar risks in treated and untreated hypertension suggest that the increased cancer risk is not explained by the use of antihypertensive treatment. | |
dc.identifier.issn | 0263-6352 | |
dc.identifier.uri | http://hdl.handle.net/1885/103506 | |
dc.publisher | Lippincott Williams & Wilkins | |
dc.source | Journal of Hypertension | |
dc.title | Hypertension, antihypertensive treatment and cancer incidence and mortality: A pooled collaborative analysis of 12 Australian and New Zealand cohorts | |
dc.type | Journal article | |
local.bibliographicCitation.issue | 1 | |
local.bibliographicCitation.lastpage | 155 | |
local.bibliographicCitation.startpage | 149 | |
local.contributor.affiliation | Harding, Jessica, Monash University | |
local.contributor.affiliation | Sooriyakumaran, Manoshayini, Monash University | |
local.contributor.affiliation | Anstey, Kaarin, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Adams, Robert, School of Medicine, University of Adelaide | |
local.contributor.affiliation | Balkau, Beverley, INSERM | |
local.contributor.affiliation | Brennan-Olsen, Sharon, Deakin University | |
local.contributor.affiliation | Briffa, Tom G, School of Population Health | |
local.contributor.affiliation | Davis, Timothy, University of Western Australia | |
local.contributor.affiliation | Dobson, Annette, University of Queensland | |
local.contributor.affiliation | Giles, Graham G, Cancer Council Victoria | |
local.contributor.affiliation | Grant, Janet, University of Adelaide | |
local.contributor.affiliation | Huxley, Rachel, University of Queensland | |
local.contributor.affiliation | Knuiman, Matthew, University of Western Australia | |
local.contributor.affiliation | Luszcz, Mary A, Flinders University | |
local.contributor.affiliation | Mitchell, Paul, University of Sydney | |
local.contributor.affiliation | Pasco, Julie A., University of Melbourne | |
local.contributor.affiliation | Reid, Christopher, Curtin University | |
local.contributor.affiliation | Simmons, David, University of Western Sydney | |
local.contributor.affiliation | Simons, Leon, University of New South Wales (St Vincent's Clinical School) | |
local.contributor.affiliation | Taylor, Anne, University of Adelaide | |
local.contributor.affiliation | Tonkin, Andrew, Monash University | |
local.contributor.affiliation | Woodward, Mark, The George Institute for Global Health | |
local.contributor.affiliation | Shaw, Jonathan, Baker IDI Heart and Diabetes Institute | |
local.contributor.affiliation | Magliano, Dianna, Baker IDI Heart and Diabetes Institute | |
local.contributor.authoremail | u4038535@anu.edu.au | |
local.contributor.authoruid | Anstey, Kaarin, u4038535 | |
local.description.embargo | 2037-12-31 | |
local.description.notes | Imported from ARIES | |
local.identifier.absfor | 110300 - CLINICAL SCIENCES | |
local.identifier.absfor | 111700 - PUBLIC HEALTH AND HEALTH SERVICES | |
local.identifier.absfor | 170100 - PSYCHOLOGY | |
local.identifier.ariespublication | U3488905xPUB8286 | |
local.identifier.citationvolume | 34 | |
local.identifier.doi | 10.1097/HJH.0000000000000770 | |
local.identifier.scopusID | 2-s2.0-84950141477 | |
local.identifier.uidSubmittedBy | U3488905 | |
local.type.status | Published Version |
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