Hypertension, antihypertensive treatment and cancer incidence and mortality: A pooled collaborative analysis of 12 Australian and New Zealand cohorts
Date
2016
Authors
Harding, Jessica
Sooriyakumaran, Manoshayini
Adams, Robert
Balkau, Beverley
Brennan-Olsen, Sharon
Briffa, Tom G
Davis, Timothy
Dobson, Annette
Giles, Graham G
Grant, Janet
Journal Title
Journal ISSN
Volume Title
Publisher
Lippincott Williams & Wilkins
Abstract
Background: Observational studies examining associations between hypertension and cancer are inconsistent. We explored the association of hypertension, graded hypertension and antihypertensive treatment with cancer incidence and mortality.
Method: Eighty-six thousand five hundred and ninety-three participants from the Australian and New Zealand Diabetes and Cancer Collaboration were linked to the National Death Index and Australian Cancer Database. Cox proportional hazards models estimated hazard ratios and 95% confidence intervals (95% CI) for the association of treated and untreated hypertension with cancer incidence and mortality.
Results: Over a median follow-up of 15.1 years, 12 070
incident and 4350 fatal cancers were identified. Untreated and treated hypertension, compared with normotension, were associated with an increased risk for cancer incidence [hazard ratio 1.06, 95% CI (1.00–1.11) and 1.09 (1.02– 1.16) respectively], and cancer mortality (1.07, 0.98–1.18) and (1.15, 1.03–1.28), respectively. When compared with untreated hypertension, treated hypertension did not have a significantly greater risk for cancer incidence (1.03,
0.97–1.10) or mortality (1.07, 0.97–1.19). A significant
dose–response relationship was observed between graded
hypertension and cancer incidence and mortality; Ptrend¼ 0.053 and Ptrend¼ 0.001, respectively. When stratified by treatment status, these relationships remained significant in untreated, but not in treated, hypertension.
Conclusion: Hypertension, both treated and untreated, is
associated with a modest increased risk for cancer incidence and mortality. Similar risks in treated and untreated hypertension suggest that the increased cancer risk is not explained by the use of antihypertensive treatment.
Description
Keywords
Citation
Collections
Source
Journal of Hypertension
Type
Journal article
Book Title
Entity type
Access Statement
License Rights
Restricted until
2037-12-31