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The dynamics of GII.4 Norovirus in Ho Chi Minh City, Vietnam

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Date

2013

Authors

My, Phan Vu Tra
Lam, Ha Minh
Thompson, Corinne
Phuc, Hoang Le
Tuyet, Pham Thi Ngoc
Vinh, Ha
Hoang, Nguyen Van Minh
Minh, PhamVan
Vinh, Nguyen Thanh
Thuy, Cao Thu

Journal Title

Journal ISSN

Volume Title

Publisher

Elsevier BV

Abstract

Norovirus (NoV) is a major cause of epidemic gastroenteritis in industrialized countries, yet the epidemiological significance of NoV in industrializing countries remains poorly understood. The spatiotemporal distribution of NoV genotypes identified in 2054 enrolled children was investigated between May 2009 and December 2010, in Ho Chi Minh City (HCMC), Vietnam. A total of 315 NoV extracted from stool samples were genotyped and GPS mapped to their source. Genogroup II NoV, particularly GII.4, were predominant, and the GII.4 strains could be subgrouped into GII.4-2006b (Minerva) and GII.4-2010 (New Orleans) variants. There was no spatiotemporal structure among the endemic GII strains; yet a significant spatiotemporal signal corresponding with the novel introduction of GII.4-2010 variant was detected. These data show that NoV GII.4 variants are highly endemic in HCMC and describe a scenario of rapid NoV strain replacement occurring in HCMC in early 2010.

Description

Keywords

Keywords: acute diarrhea; article; asymptomatic disease; child; controlled study; feces analysis; genotype; human; infant; major clinical study; microbial population dynamics; nonhuman; Norovirus; norovirus infection; nucleotide sequence; preschool child; priority Cluster; GII.4; Norovirus; Phylogenetic; Spatial; Temporal

Citation

URI

http://hdl.handle.net/1885/74334

Collections

ANU Research Publications

Source

Infection, Genetics and Evolution

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1016/j.meegid.2013.04.014

Restricted until

2037-12-31

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01_My_The_dynamics_of_GII.4_2013.pdf (2.13 MB)

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