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Modeling the Impact of DNA Methylation on the Evolution of BRCA1 in Mammals

Date

Authors

Huttley, Gavin Austin

Publisher

Society for Molecular Biology Evolution

Abstract

The modified base 5-methylcytosine (mC) plays an important functional role in the biology of mammals as an epigenetic modification and appears to exert a striking impact on the molecular evolution of mammal genomes. The collective epigenetic functions of

Keywords

Keywords: 5 methylcytosine; BRCA1 protein; dinucleotide; DNA; nucleotide; article; codon; codon substitution; CpG island; DNA methylation; DNA sequence; exon; gene mutation; mammal; maximum likelihood method; molecular evolution; molecular model; nonhuman; nucleoti BRCA1; Codon substitution model; CpG; DNA methylation; Maximum-likelihood; Molecular evolution

URI

http://hdl.handle.net/1885/77923

Collections

ANU Research Publications

Source

Molecular Biology and Evolution

Type

Journal article

DOI

10.1093/molbev/msh187