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The identification of new metallo-β-lactamase inhibitor leads from fragment-based screening

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dc.contributor.authorVella, Peter
dc.contributor.authorHussein, Waleed M
dc.contributor.authorLeung, Eleanor W W
dc.contributor.authorClayton, Daniel
dc.contributor.authorOllis, David
dc.contributor.authorMitic, Natasa
dc.contributor.authorSchenk, Gerhard
dc.contributor.authorMcGeary, Ross Peter
dc.date.accessioned2015-12-10T22:51:03Z
dc.date.issued2011
dc.date.updated2016-02-24T10:24:14Z
dc.description.abstractThe emergence of metallo-β-lactamases (MBLs) capable of hydrolysing a broad spectrum of β-lactam antibiotics is particularly concerning for the future treatment of bacterial infections. This work describes the discovery of lead compounds for the develop
dc.identifier.issn0960-894X
dc.identifier.urihttp://hdl.handle.net/1885/58869
dc.publisherPergamon-Elsevier Ltd
dc.sourceBioorganic and Medicinal Chemistry Letters
dc.subjectKeywords: captopril; centa; cephalosporin; lead; metallo beta lactamase; unclassified drug; article; bacterial infection; colorimetry; computer model; drug binding; drug identification; drug interaction; drug screening; Klebsiella pneumoniae; nonhuman; Pseudomonas Antibiotics resistance; Fragment-based screening; Inhibition assays; Metallo-ß-lactamases; Molecular docking
dc.titleThe identification of new metallo-β-lactamase inhibitor leads from fragment-based screening
dc.typeJournal article
local.bibliographicCitation.issue11
local.bibliographicCitation.lastpage3285
local.bibliographicCitation.startpage3282
local.contributor.affiliationVella, Peter, University of Queensland
local.contributor.affiliationHussein, Waleed M, University of Queensland
local.contributor.affiliationLeung, Eleanor W W, University of Queensland
local.contributor.affiliationClayton, Daniel, University of Queensland
local.contributor.affiliationOllis, David, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationMitic, Natasa, National University of Ireland-Maynooth
local.contributor.affiliationSchenk, Gerhard, University of Queensland
local.contributor.affiliationMcGeary, Ross Peter, University of Queensland
local.contributor.authoruidOllis, David, u9200080
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor030401 - Biologically Active Molecules
local.identifier.absseo970103 - Expanding Knowledge in the Chemical Sciences
local.identifier.ariespublicationu4005981xPUB462
local.identifier.citationvolume21
local.identifier.doi10.1016/j.bmcl.2011.04.027
local.identifier.scopusID2-s2.0-79956140677
local.identifier.thomsonID000290708300018
local.type.statusPublished Version

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