The identification of new metallo-β-lactamase inhibitor leads from fragment-based screening
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Vella, Peter
Hussein, Waleed M
Leung, Eleanor W W
Clayton, Daniel
Ollis, David
Mitic, Natasa
Schenk, Gerhard
McGeary, Ross Peter
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Pergamon-Elsevier Ltd
Abstract
The emergence of metallo-β-lactamases (MBLs) capable of hydrolysing a broad spectrum of β-lactam antibiotics is particularly concerning for the future treatment of bacterial infections. This work describes the discovery of lead compounds for the develop
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Bioorganic and Medicinal Chemistry Letters
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2037-12-31
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