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The identification of new metallo-β-lactamase inhibitor leads from fragment-based screening

Date

Authors

Vella, Peter

Hussein, Waleed M

Leung, Eleanor W W

Clayton, Daniel

Ollis, David

Mitic, Natasa

Schenk, Gerhard

McGeary, Ross Peter

Publisher

Pergamon-Elsevier Ltd

Abstract

The emergence of metallo-β-lactamases (MBLs) capable of hydrolysing a broad spectrum of β-lactam antibiotics is particularly concerning for the future treatment of bacterial infections. This work describes the discovery of lead compounds for the develop

Keywords

Keywords: captopril; centa; cephalosporin; lead; metallo beta lactamase; unclassified drug; article; bacterial infection; colorimetry; computer model; drug binding; drug identification; drug interaction; drug screening; Klebsiella pneumoniae; nonhuman; Pseudomonas Antibiotics resistance; Fragment-based screening; Inhibition assays; Metallo-ß-lactamases; Molecular docking

URI

http://hdl.handle.net/1885/58869

Collections

ANU Research Publications

Source

Bioorganic and Medicinal Chemistry Letters

Type

Journal article

DOI

10.1016/j.bmcl.2011.04.027

Restricted until

2037-12-31

Downloads

File

Description

01_Vella_The_identification_of_new_2011.pdf (376.28 KB)