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Engineering of a bis-chelator motif into a protein α-helix for rigid lanthanide binding and paramagnetic NMR spectroscopy

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dc.contributor.authorSwarbrick, Jamesen_AU
dc.contributor.authorUng, Phucen_AU
dc.contributor.authorSu, Xun-Chengen_AU
dc.contributor.authorMaleckis, Ansisen_AU
dc.contributor.authorChhabra, Sandeepen_AU
dc.contributor.authorGraham, Bimen_AU
dc.contributor.authorOtting, Gottfrieden_AU
dc.contributor.authorHuber, Thomasen_AU
dc.date.accessioned2015-12-10T22:51:19Z
dc.date.issued2011
dc.date.updated2016-02-24T10:24:17Z
dc.description.abstractAttachment of two nitrilotriacetic acid-based ligands to a protein α-helix in an i, i + 4 configuration produces an octadentate chelating motif that is able to bind paramagnetic lanthanide ions rigidly and with high affinity, leading to large pseudoconta
dc.identifier.issn1359-7345
dc.identifier.urihttp://hdl.handle.net/1885/58994
dc.publisherRoyal Society of Chemistry
dc.sourceChemical Communications
dc.subjectKeywords: edetic acid; lanthanide; nitrilotriacetic acid; alpha helix; article; binding affinity; cross coupling reaction; ligand binding; nuclear magnetic resonance spectroscopy; protein binding; protein engineering; protein motif; protein protein interaction; Ami
dc.titleEngineering of a bis-chelator motif into a protein α-helix for rigid lanthanide binding and paramagnetic NMR spectroscopy
dc.typeJournal article
local.bibliographicCitation.issue26
local.bibliographicCitation.lastpage7370
local.bibliographicCitation.startpage7368
local.contributor.affiliationSwarbrick, James, Monash University
local.contributor.affiliationUng, Phuc, Monash Institute of Pharmaceutical Sciences
local.contributor.affiliationSu, Xun-Cheng, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationMaleckis, Ansis, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationChhabra, Sandeep, Monash Institute of Pharmaceutical Sciences
local.contributor.affiliationHuber, Thomas, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationOtting, Gottfried, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationGraham, Bim, Monash University
local.contributor.authoruidSu, Xun-Cheng, u4175170
local.contributor.authoruidMaleckis, Ansis, u4777328
local.contributor.authoruidHuber, Thomas, u9512183
local.contributor.authoruidOtting, Gottfried, u4046684
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor060112 - Structural Biology (incl. Macromolecular Modelling)
local.identifier.absfor030503 - Organic Chemical Synthesis
local.identifier.absfor030606 - Structural Chemistry and Spectroscopy
local.identifier.absseo860803 - Human Pharmaceutical Treatments (e.g. Antibiotics)
local.identifier.ariespublicationu4005981xPUB468
local.identifier.citationvolume47
local.identifier.doi10.1039/c1cc11893e
local.identifier.scopusID2-s2.0-79959383052
local.identifier.thomsonID000291823400020
local.type.statusPublished Version

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