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Engineering of a bis-chelator motif into a protein α-helix for rigid lanthanide binding and paramagnetic NMR spectroscopy

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Date

2011

Authors

Swarbrick, James
Ung, Phuc
Su, Xun-Cheng
Maleckis, Ansis
Chhabra, Sandeep
Graham, Bim
Otting, Gottfried
Huber, Thomas

Journal Title

Journal ISSN

Volume Title

Publisher

Royal Society of Chemistry

Abstract

Attachment of two nitrilotriacetic acid-based ligands to a protein α-helix in an i, i + 4 configuration produces an octadentate chelating motif that is able to bind paramagnetic lanthanide ions rigidly and with high affinity, leading to large pseudoconta

Description

Keywords

Keywords: edetic acid; lanthanide; nitrilotriacetic acid; alpha helix; article; binding affinity; cross coupling reaction; ligand binding; nuclear magnetic resonance spectroscopy; protein binding; protein engineering; protein motif; protein protein interaction; Ami

Citation

URI

http://hdl.handle.net/1885/58994

Collections

ANU Research Publications

Source

Chemical Communications

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1039/c1cc11893e

Restricted until

2037-12-31

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Description
01_Swarbrick_Engineering_of_a_bis-chelator_2011.pdf (1.21 MB)

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