Hepatic ischemia reperfusion injury: Pathogenic mechanisms and basis for hepatoprotection

Date

Authors

Teoh, Narcissus

Farrell, Geoff C

Publisher

Blackwell Publishing Ltd

Abstract

This review highlights recent advances in our understanding of mechanisms underlying repeffusion injury to the liver after warm hepatic ischemia. Sinusoidal endothelial cells and hepatocytes are targets of injury in the early 'cytotoxic' phase, although p

Keywords

Keywords: cell adhesion molecule; chemokine; cytokine; interleukin 1; interleukin 6; nitric oxide; reactive oxygen metabolite; tumor necrosis factor; tumor necrosis factor alpha; cell death; energy metabolism; human; human cell; hypoxia; inflammatory cell; Kupffer Adenosine; Adhesion molecules; Cell-cycle entry; Hepatic ischemia reperfusion injury; Ischemic preconditioning; Kupffer cells; Microcirculation; Neutrophils; Nitric oxide; Reactive oxygen species; Tumor necrosis factor

URI

http://hdl.handle.net/1885/51310

Collections

ANU Research Publications

Source

Journal of Gastroenterology and Hepatology

Type

Journal article

DOI

10.1046/j.1440-1746.2003.03056.x

Restricted until

2037-12-31

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Description

01_Teoh_Hepatic_ischemia_reperfusion_2003.pdf (181.84 KB)