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A hyperactive mutant of interferon-regulatory factor 4

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dc.contributor.authorKang, Chol-Ho
dc.contributor.authorHartmann, Enno
dc.contributor.authorMenke, Lisa
dc.contributor.authorStaudenraus, Daniel
dc.contributor.authorAbass, E
dc.contributor.authorRaifer, H
dc.contributor.authorPorapu, Alekya
dc.contributor.authorCamara, B
dc.contributor.authorBruestle, Anne
dc.contributor.authorPinkenburg, Olaf
dc.contributor.authorBieringer, Maria
dc.contributor.authorLohoff, Michael
dc.date.accessioned2023-06-02T04:39:38Z
dc.date.issued2019
dc.date.updated2022-03-27T07:31:13Z
dc.description.abstractWe found that deletion of the final 30 amino acids of transcription factor IRF4's (interferon‐regulatory factor) C‐terminus creates hyperactive IRF4. When introduced into IRF4‐deficient CD4+ or CD8+ T cells, more type 17 differentiation was found compared to WT IRF4. Interestingly, Th9 differentiation and Th2‐linked IL‐13 production were much less altered.en_AU
dc.description.sponsorshipThese studies were funded by the DFG (grant LO 396/8-1 to M.L.), the DZIF (M.L. and O.P.),Rh ̈on-Klinikum A.G, and Kempkes Stiftung(to M.B.en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn0014-2980en_AU
dc.identifier.urihttp://hdl.handle.net/1885/292328
dc.language.isoen_AUen_AU
dc.publisherWiley-VCH Verlag GMBHen_AU
dc.rights© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheimen_AU
dc.sourceEuropean Journal of Immunologyen_AU
dc.titleA hyperactive mutant of interferon-regulatory factor 4en_AU
dc.typeJournal articleen_AU
local.bibliographicCitation.issue5en_AU
local.bibliographicCitation.lastpage815en_AU
local.bibliographicCitation.startpage812en_AU
local.contributor.affiliationKang, Chol-Ho, University of Marburgen_AU
local.contributor.affiliationHartmann, Enno, Philipps University Marburgen_AU
local.contributor.affiliationMenke, Lisa, Philipps University Marburgen_AU
local.contributor.affiliationStaudenraus, Daniel, Philipps University Marburgen_AU
local.contributor.affiliationAbass, E, University of Marburgen_AU
local.contributor.affiliationRaifer, H, University of Marburgen_AU
local.contributor.affiliationPorapu, Alekya, Philipps University Marburgen_AU
local.contributor.affiliationCamara, B, University of Marburgen_AU
local.contributor.affiliationBruestle, Anne, College of Health and Medicine, ANUen_AU
local.contributor.affiliationPinkenburg, Olaf, University of Marburgen_AU
local.contributor.affiliationBieringer, Maria, University of Marburgen_AU
local.contributor.affiliationLohoff, Michael, University of Marburgen_AU
local.contributor.authoruidBruestle, Anne, u5691124en_AU
local.description.embargo2099-12-31
local.description.notesImported from ARIESen_AU
local.identifier.absfor320404 - Cellular immunologyen_AU
local.identifier.ariespublicationu3102795xPUB1542en_AU
local.identifier.citationvolume49en_AU
local.identifier.doi10.1002/eji.201847530en_AU
local.identifier.scopusID2-s2.0-85054190069
local.publisher.urlhttps://www.wiley.com/en-gben_AU
local.type.statusPublished Versionen_AU

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