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A hyperactive mutant of interferon-regulatory factor 4

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Date

2019

Authors

Kang, Chol-Ho
Hartmann, Enno
Menke, Lisa
Staudenraus, Daniel
Abass, E
Raifer, H
Porapu, Alekya
Camara, B
Bruestle, Anne
Pinkenburg, Olaf

Journal Title

Journal ISSN

Volume Title

Publisher

Wiley-VCH Verlag GMBH

Abstract

We found that deletion of the final 30 amino acids of transcription factor IRF4's (interferon‐regulatory factor) C‐terminus creates hyperactive IRF4. When introduced into IRF4‐deficient CD4+ or CD8+ T cells, more type 17 differentiation was found compared to WT IRF4. Interestingly, Th9 differentiation and Th2‐linked IL‐13 production were much less altered.

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Keywords

Citation

URI

http://hdl.handle.net/1885/292328

Collections

ANU Research Publications

Source

European Journal of Immunology

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1002/eji.201847530

Restricted until

2099-12-31

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Eur J Immunol - 2018 - Kang - A hyperactive mutant of interferon‐regulatory factor 4.pdf (1.07 MB)

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