A consensus epitope prediction approach identifies the breadth of murine T CD8+ -cell responses to vaccinia virus

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dc.contributor.authorMoutaftsi, Magdalini
dc.contributor.authorPeters, Bjoern
dc.contributor.authorPasquetto, Valerie
dc.contributor.authorTscharke, David
dc.contributor.authorSidney, John
dc.contributor.authorBui, Huynh-Hoa
dc.contributor.authorGrey, Howard
dc.contributor.authorSette, Alessandro
dc.date.accessioned2015-12-08T22:09:09Z
dc.date.issued2006
dc.date.updated2015-12-08T07:22:33Z
dc.description.abstractThe value of predictive algorithms for identifying CD8+ T (TCD8+)-cell epitopes has not been adequately tested experimentally. Here we demonstrate that conventional bioinformatic methods predict the vast majority of TCD8+-cell epitopes derived from vaccinia virus WR strain (VACV-WR) in the H-2b mouse model. This approach reveals the breadth of T-cell responses to vaccinia, a widely studied murine viral infection model, and may provide a tool for developing comprehensive antigenic maps of any complex pathogen.
dc.identifier.issn1087-0156
dc.identifier.urihttp://hdl.handle.net/1885/28900
dc.publisherNature Publishing Group
dc.sourceNature Biotechnology
dc.subjectKeywords: Algorithms; Antigens; Biomarkers; Biotechnology; Cell culture; Mathematical models; Viruses; Breadth; Consensus epitopes; Predicitve algorithms; T-cell; Cells; cytokine; DNA polymerase; epitope; gamma interferon; major histocompatibility antigen class 1;
dc.titleA consensus epitope prediction approach identifies the breadth of murine T CD8+ -cell responses to vaccinia virus
dc.typeJournal article
local.bibliographicCitation.issue7
local.bibliographicCitation.lastpage19
local.bibliographicCitation.startpage817
local.contributor.affiliationMoutaftsi, Magdalini, La Jolla Institute for Allergy and Immunology
local.contributor.affiliationPeters, Bjoern, La Jolla Institute for Allergy and Immunology
local.contributor.affiliationPasquetto, Valerie, La Jolla Institute for Allergy and Immunology
local.contributor.affiliationTscharke, David, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationSidney, John, La Jolla Institute for Allergy and Immunology
local.contributor.affiliationBui, Huynh-Hoa, La Jolla Institute for Allergy and Immunology
local.contributor.affiliationGrey, Howard, La Jolla Institute for Allergy and Immunology
local.contributor.affiliationSette, Alessandro, La Jolla Institute for Allergy and Immunology
local.contributor.authoruidTscharke, David, u4334102
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor110704 - Cellular Immunology
local.identifier.ariespublicationu4325460xPUB61
local.identifier.citationvolume24
local.identifier.doi10.1038/nbt1215
local.identifier.scopusID2-s2.0-33746132748
local.type.statusPublished Version

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