A consensus epitope prediction approach identifies the breadth of murine T CD8+ -cell responses to vaccinia virus
Date
Authors
Moutaftsi, Magdalini
Peters, Bjoern
Pasquetto, Valerie
Tscharke, David
Sidney, John
Bui, Huynh-Hoa
Grey, Howard
Sette, Alessandro
Journal Title
Journal ISSN
Volume Title
Publisher
Nature Publishing Group
Abstract
The value of predictive algorithms for identifying CD8+ T (TCD8+)-cell epitopes has not been adequately tested experimentally. Here we demonstrate that conventional bioinformatic methods predict the vast majority of TCD8+-cell epitopes derived from vaccinia virus WR strain (VACV-WR) in the H-2b mouse model. This approach reveals the breadth of T-cell responses to vaccinia, a widely studied murine viral infection model, and may provide a tool for developing comprehensive antigenic maps of any complex pathogen.
Description
Citation
Collections
Source
Nature Biotechnology
Type
Book Title
Entity type
Access Statement
License Rights
DOI
Restricted until
2037-12-31