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The Shigella flexneri serotype Y vaccine candidate SFL124 originated from a serotype 2a background

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dc.contributor.authorRoberts, Fleur
dc.contributor.authorJennison, Amy
dc.contributor.authorVerma, Naresh
dc.date.accessioned2015-12-13T22:58:46Z
dc.date.issued2005
dc.date.updated2015-12-12T07:24:17Z
dc.description.abstractShigella flexneri is endemic in most developing countries and responsible for the highest mortality rate among the Shigella species. The attenuated serotype Y S. flexneri strain SFL124 has been used as the parental strain for the development of recombinant vaccines expressing multiple O-antigen structures. During the development of one such multivalent vaccine, a region of gtrII homology was found in SFL124. Sequencing and analysis of this region revealed the presence of an insertion element interrupted serotype 2a serotype-conversion locus in the serotype Y vaccine strain SFL124. The data presented suggests that SFL124 has derived from a serotype 2a background.
dc.identifier.issn0928-8244
dc.identifier.urihttp://hdl.handle.net/1885/83453
dc.publisherElsevier
dc.sourceFEMS Immunology and Medical Microbiology
dc.subjectKeywords: bacterial vaccine; glucosyltransferase; O antigen; recombinant vaccine; shigella flexneri vaccine; Shigella vaccine; unclassified drug; antigen expression; article; bacterial strain; controlled study; gene insertion; gene locus; microbial attenuation; non Glucosyl transferases; Serotype reversion; Shigella flexneri
dc.titleThe Shigella flexneri serotype Y vaccine candidate SFL124 originated from a serotype 2a background
dc.typeJournal article
local.bibliographicCitation.issue2
local.bibliographicCitation.lastpage289
local.bibliographicCitation.startpage285
local.contributor.affiliationRoberts, Fleur, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationJennison, Amy, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationVerma, Naresh, College of Medicine, Biology and Environment, ANU
local.contributor.authoruidRoberts, Fleur, u4017760
local.contributor.authoruidJennison, Amy, u4022529
local.contributor.authoruidVerma, Naresh, u9309713
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor110801 - Medical Bacteriology
local.identifier.ariespublicationMigratedxPub11728
local.identifier.citationvolume45
local.identifier.doi10.1016/j.femsim.2005.05.002
local.identifier.scopusID2-s2.0-22844452320
local.type.statusPublished Version

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