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The Shigella flexneri serotype Y vaccine candidate SFL124 originated from a serotype 2a background

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Date

2005

Authors

Roberts, Fleur
Jennison, Amy
Verma, Naresh

Journal Title

Journal ISSN

Volume Title

Publisher

Elsevier

Abstract

Shigella flexneri is endemic in most developing countries and responsible for the highest mortality rate among the Shigella species. The attenuated serotype Y S. flexneri strain SFL124 has been used as the parental strain for the development of recombinant vaccines expressing multiple O-antigen structures. During the development of one such multivalent vaccine, a region of gtrII homology was found in SFL124. Sequencing and analysis of this region revealed the presence of an insertion element interrupted serotype 2a serotype-conversion locus in the serotype Y vaccine strain SFL124. The data presented suggests that SFL124 has derived from a serotype 2a background.

Description

Keywords

Keywords: bacterial vaccine; glucosyltransferase; O antigen; recombinant vaccine; shigella flexneri vaccine; Shigella vaccine; unclassified drug; antigen expression; article; bacterial strain; controlled study; gene insertion; gene locus; microbial attenuation; non Glucosyl transferases; Serotype reversion; Shigella flexneri

Citation

URI

http://hdl.handle.net/1885/83453

Collections

ANU Research Publications

Source

FEMS Immunology and Medical Microbiology

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1016/j.femsim.2005.05.002

Restricted until

2037-12-31

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01_Roberts_The_Shigella_flexneri_serotype_2005.pdf (144.54 KB)

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