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Essential role of membrane cholesterol in accelerated BCR internalization and uncoupling from NF-kB in B cell clonal anergy

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dc.contributor.authorBlery, Mathieu
dc.contributor.authorTze, Lina
dc.contributor.authorMiosge, Lisa
dc.contributor.authorJun, Jesse
dc.contributor.authorGoodnow, Christopher
dc.date.accessioned2015-12-13T22:41:47Z
dc.date.issued2006
dc.date.updated2015-12-11T10:03:28Z
dc.description.abstractDivergent hypotheses exist to explain how signaling by the B cell receptor (BCR) is initiated after antigen binding and how it is qualitatively altered in anergic B cells to selectively uncouple from nuclear factor κB and c-Jun N-terminal kinase pathways
dc.identifier.issn0022-1007
dc.identifier.urihttp://hdl.handle.net/1885/78666
dc.publisherRockefeller University Press
dc.sourceJournal of Experimental Medicine
dc.subjectKeywords: B lymphocyte receptor; cholesterol; immunoglobulin D; immunoglobulin enhancer binding protein; methyl beta cyclodextrin; sphingolipid; stress activated protein kinase; animal cell; animal experiment; antigen binding; article; B lymphocyte; cell membrane;
dc.titleEssential role of membrane cholesterol in accelerated BCR internalization and uncoupling from NF-kB in B cell clonal anergy
dc.typeJournal article
local.bibliographicCitation.issue7
local.bibliographicCitation.lastpage1783
local.bibliographicCitation.startpage1773
local.contributor.affiliationBlery, Mathieu , College of Medicine, Biology and Environment, ANU
local.contributor.affiliationTze, Lina, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMiosge, Lisa, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationJun, Jesse, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationGoodnow, Christopher, College of Medicine, Biology and Environment, ANU
local.contributor.authoruidBlery, Mathieu , u1861590
local.contributor.authoruidTze, Lina, u4079707
local.contributor.authoruidMiosge, Lisa, u9817053
local.contributor.authoruidJun, Jesse, u3274002
local.contributor.authoruidGoodnow, Christopher, u9710462
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor110703 - Autoimmunity
local.identifier.ariespublicationMigratedxPub7273
local.identifier.citationvolume203
local.identifier.doi10.1084/jem.20060552
local.identifier.scopusID2-s2.0-33745867300
local.type.statusPublished Version

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