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Essential role of membrane cholesterol in accelerated BCR internalization and uncoupling from NF-kB in B cell clonal anergy

Date

Authors

Blery, Mathieu

Tze, Lina

Miosge, Lisa

Jun, Jesse

Goodnow, Christopher

Publisher

Rockefeller University Press

Abstract

Divergent hypotheses exist to explain how signaling by the B cell receptor (BCR) is initiated after antigen binding and how it is qualitatively altered in anergic B cells to selectively uncouple from nuclear factor κB and c-Jun N-terminal kinase pathways

Keywords

Keywords: B lymphocyte receptor; cholesterol; immunoglobulin D; immunoglobulin enhancer binding protein; methyl beta cyclodextrin; sphingolipid; stress activated protein kinase; animal cell; animal experiment; antigen binding; article; B lymphocyte; cell membrane;

URI

http://hdl.handle.net/1885/78666

Collections

ANU Research Publications

Source

Journal of Experimental Medicine

Type

Journal article

DOI

10.1084/jem.20060552

Restricted until

2037-12-31

Downloads

File

Description

01_Blery_Essential_role_of_membrane_2006.pdf (2.63 MB)