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T-cell regulation by casitas B-lineage lymphoma (Cblb) is a critical failsafe against autoimmune disease due to autoimmune regulator (Aire) deﬁciency

Date

Authors

Teh, Charis

Daley, Stephen

Enders, Anselm

Goodnow, Christopher

Publisher

National Academy of Sciences (USA)

Abstract

Autoimmune polyendocrinopathy syndrome type 1 (APS1) results from homozygous Aire mutations that cripple thymic deletion of organ-specific T cells. The clinical course in man and mouse is characterized by high variability both in the latent period before

Keywords

Keywords: autoimmune regulator protein; CD28 antigen; Fas ligand; transcription factor FOXP3; autoimmune regulator protein; Cbl protein; Cblb protein, mouse; signal transducing adaptor protein; transcription factor; acinar cell; animal cell; animal tissue; article; Anergy; Autoimmunity; Pancreatitis; Tolerance; Ubiquitin ligase

URI

http://hdl.handle.net/1885/36369

Collections

ANU Research Publications

Source

PNAS - Proceedings of the National Academy of Sciences of the United States of America

Type

Journal article

DOI

10.1073/pnas.1009209107

Restricted until

2037-12-31

Downloads

File

Description

01_Teh_T-cell_regulation_by_casitas_2010.pdf (981.01 KB)

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