Cultural advice

The Australian National University acknowledges, celebrates and pays our respects to the Ngunnawal and Ngambri people of the Canberra region and to all First Nations Australians on whose traditional lands we meet and work, and whose cultures are among the oldest continuing cultures in human history.

Aboriginal and Torres Strait Islander peoples are advised that ANU Library collections may include images, names, voices, and other representations of deceased persons.

Material in the collection may contain terms, language or views that reflect the period in which the item was created and may be considered inappropriate today.

Evidence for Gliotoxin-Glutathione Conjugate Adducts

Simple item page
dc.contributor.authorBernardo, Paul
dc.contributor.authorChai, Christina
dc.contributor.authorDeeble, Geoffrey
dc.contributor.authorLiu, Xi
dc.contributor.authorWaring, Paul
dc.date.accessioned2015-12-10T23:05:49Z
dc.date.issued2001
dc.date.updated2015-12-10T08:49:13Z
dc.description.abstractThe equilibrium constant for the gliotoxin/glutathione pair was found to be 1200±100M-1 at pH 7.0 at 25°C. Under conditions where the reaction was quenched rapidly with the addition of acid, gliotoxin-glutathione conjugate adducts were detected.
dc.identifier.issn0960-894X
dc.identifier.urihttp://hdl.handle.net/1885/62519
dc.publisherPergamon-Elsevier Ltd
dc.sourceBioorganic and Medicinal Chemistry Letters
dc.subjectKeywords: gliotoxin; glutathione; article; drug conjugation; drug mechanism; drug structure; equilibrium constant; high performance liquid chromatography; nuclear magnetic resonance spectroscopy; pH; reaction analysis; Chromatography, High Pressure Liquid; Gliotoxi
dc.titleEvidence for Gliotoxin-Glutathione Conjugate Adducts
dc.typeJournal article
local.bibliographicCitation.lastpage485
local.bibliographicCitation.startpage483
local.contributor.affiliationBernardo, Paul, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationChai, Christina, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationDeeble, Geoffrey, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationLiu, Xi, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationWaring, Paul, College of Medicine, Biology and Environment, ANU
local.contributor.authoruidBernardo, Paul, u4006401
local.contributor.authoruidChai, Christina, u8615775
local.contributor.authoruidDeeble, Geoffrey, u8002483
local.contributor.authoruidLiu, Xi, u9905528
local.contributor.authoruidWaring, Paul, u4021263
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor030499 - Medicinal and Biomolecular Chemistry not elsewhere classified
local.identifier.ariespublicationMigratedxPub707
local.identifier.citationvolume11
local.identifier.doi10.1016/S0960-894X(00)00696-X
local.identifier.scopusID2-s2.0-0035952310
local.type.statusPublished Version

Downloads

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
01_Bernardo_Evidence_for_2001.pdf
Size:
108.76 KB
Format:
Adobe Portable Document Format
Download

Collections

ANU Research Publications

DSpace software copyright © 2002-2026 LYRASIS