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Evidence for Gliotoxin-Glutathione Conjugate Adducts

Date

2001

Authors

Bernardo, Paul
Chai, Christina
Deeble, Geoffrey
Liu, Xi
Waring, Paul

Journal Title

Journal ISSN

Volume Title

Publisher

Pergamon-Elsevier Ltd

Abstract

The equilibrium constant for the gliotoxin/glutathione pair was found to be 1200±100M-1 at pH 7.0 at 25°C. Under conditions where the reaction was quenched rapidly with the addition of acid, gliotoxin-glutathione conjugate adducts were detected.

Description

Keywords

Keywords: gliotoxin; glutathione; article; drug conjugation; drug mechanism; drug structure; equilibrium constant; high performance liquid chromatography; nuclear magnetic resonance spectroscopy; pH; reaction analysis; Chromatography, High Pressure Liquid; Gliotoxi

Citation

URI

http://hdl.handle.net/1885/62519

Collections

ANU Research Publications

Source

Bioorganic and Medicinal Chemistry Letters

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1016/S0960-894X(00)00696-X

Restricted until

2037-12-31

Downloads

File
Description
01_Bernardo_Evidence_for_2001.pdf (108.76 KB)

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