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Cell surface-expressed cation-independent mannose 6-phosphate receptor (CD222) binds enzymatically active heparanase independently of mannose 6-phosphate to promote extracellular matrix degradation

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Date

2008

Authors

Wood, Robert
Hulett, Mark

Journal Title

Journal ISSN

Volume Title

Publisher

American Society for Biochemistry and Molecular Biology Inc

Abstract

Heparanase is a β-D-endoglucuronidase that cleaves heparan sulfate, an important structural component of the extracellular matrix (ECM) and vascular basement membrane (BM). The cleavage of heparan sulfate by heparanase-expressing cells, such as activated

Description

Keywords

Keywords: Adhesion; Cell adhesion; Cell culture; Cell membranes; Cytology; Degradation; Electric discharge machining; Endothelial cells; Enzyme inhibition; Pathology; Positive ions; Tumors; Acidic ph; Angiogenesis; Basement membranes; Cell invasions; Cell lines; Ce

Citation

URI

http://hdl.handle.net/1885/33038

Collections

ANU Research Publications

Source

Journal of Biological Chemistry

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1074/jbc.M708723200

Restricted until

2037-12-31

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01_Wood_Cell_surface-expressed_2008.pdf (508.8 KB)

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