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The accumulation of circulating histones on heparan sulphate in the capillary glycocalyx of the lungs

Date

Authors

Freeman, Craig

Knox, Karen

Bell, Jessica

Lobov, Sergey

King, David

Senden, Timothy

Stephens, Ross

Parish, Christopher

Publisher

Pergamon-Elsevier Ltd

Abstract

Recent findings on the role of circulating histone proteins in mediating acute lung injury prompted us to investigate whether there is a specific mechanism for accumulation of histones in the lungs. Binding sites for polycations are already known in the v

Keywords

Keywords: Acute lung injury; Biodistributions; Charge interactions; Heparan sulphate; Histones; Intravenous injections; Lung endothelium; Positively charged; Amino acids; Biological organs; Blood vessels; Imaging techniques; Sulfur compounds; Proteins; heparan sulf Acute lung injury; Heparan sulphate; Histones; Lung endothelium

URI

http://hdl.handle.net/1885/72692

Collections

ANU Research Publications

Source

Biomaterials

Type

Journal article

DOI

10.1016/j.biomaterials.2013.03.091

Restricted until

2037-12-31

Downloads

File

Description

01_Freeman_The_accumulation_of_2013.pdf (1.07 MB)