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Synthesis of simple analogues of methyllycaconitine - an efficient method for the preparation of the N -substituted anthranilate pharmacophore

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dc.contributor.authorBarker, David
dc.contributor.authorBrimble, Margaret A
dc.contributor.authorMcLeod, Malcolm
dc.date.accessioned2015-12-10T22:24:04Z
dc.date.issued2004
dc.date.updated2015-12-09T09:13:37Z
dc.description.abstractThe synthesis of several A and AE ring analogues of the alkaloid methyllycaconitine is reported. The key 2-(2″-methylsuccinimido)benzoate ester pharmacophore is introduced using an efficient two step procedure. Esterification of the alcohol precursors w
dc.identifier.issn0040-4020
dc.identifier.urihttp://hdl.handle.net/1885/53091
dc.publisherElsevier
dc.sourceTetrahedron
dc.subjectKeywords: 2 (2'' methylsuccinimido)benzoate; acid anhydride; alkaloid derivative; anthranilic acid; benzoic acid derivative; methyllycaconitine; sodium borohydride; trifluoroacetic acid; unclassified drug; Aconitum; article; drug structure; drug synthesis; esterifi Alkaloids; Anthranilate esters; Methyllycaconitine; Nicotinic acetylcholine receptors
dc.titleSynthesis of simple analogues of methyllycaconitine - an efficient method for the preparation of the N -substituted anthranilate pharmacophore
dc.typeJournal article
local.bibliographicCitation.issue28
local.bibliographicCitation.lastpage5963
local.bibliographicCitation.startpage5953
local.contributor.affiliationBarker, David, University of Sydney
local.contributor.affiliationBrimble, Margaret A, University of Auckland
local.contributor.affiliationMcLeod, Malcolm, College of Physical and Mathematical Sciences, ANU
local.contributor.authoruidMcLeod, Malcolm, u4045340
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor030503 - Organic Chemical Synthesis
local.identifier.ariespublicationu4005981xPUB264
local.identifier.citationvolume60
local.identifier.doi10.1016/j.tet.2004.05.024
local.identifier.scopusID2-s2.0-2942750323
local.type.statusPublished Version

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