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Synthesis of simple analogues of methyllycaconitine - an efficient method for the preparation of the N -substituted anthranilate pharmacophore

Date

Authors

Barker, David

Brimble, Margaret A

McLeod, Malcolm

Publisher

Elsevier

Abstract

The synthesis of several A and AE ring analogues of the alkaloid methyllycaconitine is reported. The key 2-(2″-methylsuccinimido)benzoate ester pharmacophore is introduced using an efficient two step procedure. Esterification of the alcohol precursors w

Keywords

Keywords: 2 (2'' methylsuccinimido)benzoate; acid anhydride; alkaloid derivative; anthranilic acid; benzoic acid derivative; methyllycaconitine; sodium borohydride; trifluoroacetic acid; unclassified drug; Aconitum; article; drug structure; drug synthesis; esterifi Alkaloids; Anthranilate esters; Methyllycaconitine; Nicotinic acetylcholine receptors

URI

http://hdl.handle.net/1885/53091

Collections

ANU Research Publications

Source

Tetrahedron

Type

Journal article

DOI

10.1016/j.tet.2004.05.024

Restricted until

2037-12-31

Downloads

File

Description

01_Barker_Synthesis_of_simple_analogues_2004.pdf (357.4 KB)