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Diverse chemotypes disrupt ion homeostasis in the malaria parasite

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Date

2014

Authors

Lehane, Adele
Ridgway, Melanie
Baker, Eileen
Kirk, Kiaran

Journal Title

Journal ISSN

Volume Title

Publisher

Blackwell Publishing Ltd

Abstract

The antimalarial spiroindolones disrupt Plasmodium falciparumNa+ regulation and induce an alkalinization of the parasite cytosol. It has been proposed that they do so by inhibiting PfATP4, a parasite plasma membrane P-type ATPase postulated to export Na+

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Keywords

Citation

URI

http://hdl.handle.net/1885/26961

Collections

ANU Research Publications

Source

Molecular Microbiology

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1111/mmi.12765

Restricted until

2037-12-31

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01_Lehane_Diverse_chemotypes_disrupt_ion_2014.pdf (935.78 KB)

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