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The structure of the C-terminal helical bundle in glutathione transferase M2-2 determines its ability to inhibit the cardiac ryanodine receptor

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dc.contributor.authorHewawasam, Ruwani
dc.contributor.authorLiu, Dan
dc.contributor.authorCasarotto, Marco
dc.contributor.authorDulhunty, Angela
dc.contributor.authorBoard, Philip
dc.date.accessioned2015-12-07T22:14:20Z
dc.date.issued2010
dc.date.updated2016-02-24T11:26:24Z
dc.description.abstractCa2+ release from the sarcoplasmic reticulum through cardiac ryanodine receptors (RyR2) is essential for heart function and is inhibited by the carboxy terminal domain of glutathione transferase M2-2 (GSTM2-C) and derivative fragments containing helix 6.
dc.identifier.issn0006-2952
dc.identifier.urihttp://hdl.handle.net/1885/17374
dc.publisherElsevier
dc.sourceBiochemical Pharmacology
dc.subjectKeywords: alanine; aspartic acid; calcium ion; glutathione transferase M2; glutathione transferase M2 2; leucine; phenylalanine; tryptophan; tyrosine; unclassified drug; amino acid substitution; article; calcium transport; carboxy terminal sequence; cell vacuole; c Calcium release from cardiac sarcoplasmic reticulum; Calcium release from skeletal sarcoplasmic reticulum; Cardiac RyR2 channels; Glutathione transferase GSTM2-2; Lipid bilayer single channel experiments; Skeletal RyR1 channels
dc.titleThe structure of the C-terminal helical bundle in glutathione transferase M2-2 determines its ability to inhibit the cardiac ryanodine receptor
dc.typeJournal article
local.bibliographicCitation.issue3
local.bibliographicCitation.lastpage388
local.bibliographicCitation.startpage381
local.contributor.affiliationHewawasam, Ruwani, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationLiu, Dan, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationCasarotto, Marco, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationDulhunty, Angela, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBoard, Philip, College of Medicine, Biology and Environment, ANU
local.contributor.authoruidHewawasam, Ruwani, u4279752
local.contributor.authoruidLiu, Dan, u4245938
local.contributor.authoruidCasarotto, Marco, u9611346
local.contributor.authoruidDulhunty, Angela, u8404877
local.contributor.authoruidBoard, Philip, u7701651
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor060110 - Receptors and Membrane Biology
local.identifier.ariespublicationu4897219xPUB1
local.identifier.citationvolume80
local.identifier.doi10.1016/j.bcp.2010.04.019
local.identifier.scopusID2-s2.0-77953356388
local.identifier.thomsonID000278712100011
local.type.statusPublished Version

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