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The structure of the C-terminal helical bundle in glutathione transferase M2-2 determines its ability to inhibit the cardiac ryanodine receptor

Date

Authors

Hewawasam, Ruwani

Liu, Dan

Casarotto, Marco

Dulhunty, Angela

Board, Philip

Publisher

Elsevier

Abstract

Ca2+ release from the sarcoplasmic reticulum through cardiac ryanodine receptors (RyR2) is essential for heart function and is inhibited by the carboxy terminal domain of glutathione transferase M2-2 (GSTM2-C) and derivative fragments containing helix 6.

Keywords

Keywords: alanine; aspartic acid; calcium ion; glutathione transferase M2; glutathione transferase M2 2; leucine; phenylalanine; tryptophan; tyrosine; unclassified drug; amino acid substitution; article; calcium transport; carboxy terminal sequence; cell vacuole; c Calcium release from cardiac sarcoplasmic reticulum; Calcium release from skeletal sarcoplasmic reticulum; Cardiac RyR2 channels; Glutathione transferase GSTM2-2; Lipid bilayer single channel experiments; Skeletal RyR1 channels

URI

http://hdl.handle.net/1885/17374

Collections

ANU Research Publications

Source

Biochemical Pharmacology

Type

Journal article

DOI

10.1016/j.bcp.2010.04.019

Restricted until

2037-12-31

Downloads

File

Description

01_Hewawasam_The_structure_of_the_2010.pdf (469.94 KB)