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The structure of the C-terminal helical bundle in glutathione transferase M2-2 determines its ability to inhibit the cardiac ryanodine receptor

Date

2010

Authors

Hewawasam, Ruwani
Liu, Dan
Casarotto, Marco
Dulhunty, Angela
Board, Philip

Journal Title

Journal ISSN

Volume Title

Publisher

Elsevier

Abstract

Ca2+ release from the sarcoplasmic reticulum through cardiac ryanodine receptors (RyR2) is essential for heart function and is inhibited by the carboxy terminal domain of glutathione transferase M2-2 (GSTM2-C) and derivative fragments containing helix 6.

Description

Keywords

Keywords: alanine; aspartic acid; calcium ion; glutathione transferase M2; glutathione transferase M2 2; leucine; phenylalanine; tryptophan; tyrosine; unclassified drug; amino acid substitution; article; calcium transport; carboxy terminal sequence; cell vacuole; c Calcium release from cardiac sarcoplasmic reticulum; Calcium release from skeletal sarcoplasmic reticulum; Cardiac RyR2 channels; Glutathione transferase GSTM2-2; Lipid bilayer single channel experiments; Skeletal RyR1 channels

Citation

Source

Biochemical Pharmacology

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1016/j.bcp.2010.04.019

Restricted until

2037-12-31