Implications of epithelial–mesenchymal plasticity for heterogeneity in colorectal cancer
| dc.contributor.author | Pereira, Lloyd | |
| dc.contributor.author | Mariadason, John M. | |
| dc.contributor.author | Hannan, Ross D. | |
| dc.contributor.author | Dhillon, Amardeep S. | |
| dc.date.accessioned | 2016-01-29T04:59:45Z | |
| dc.date.available | 2016-01-29T04:59:45Z | |
| dc.date.issued | 2015-02-02 | |
| dc.date.updated | 2018-11-29T08:17:20Z | |
| dc.description.abstract | Colorectal cancer (CRC) is a genetically heterogeneous disease that develops and progresses through several distinct pathways characterized by genomic instability. In recent years, it has emerged that inherent plasticity in some populations of CRC cells can contribute to heterogeneity in differentiation state, metastatic potential, therapeutic response, and disease relapse. Such plasticity is thought to arise through interactions between aberrant signaling events, including persistent activation of the APC/β-catenin and KRAS/BRAF/ERK pathways, and the tumor microenvironment. Here, we highlight key concepts and evidence relating to the role of epithelial-mesenchymal plasticity as a driver of CRC progression and stratification of the disease into distinct molecular and clinicopathological subsets. | |
| dc.description.sponsorship | This work was supported by grants from the National Health and Medical Research Council of Australia (to Amardeep Singh Dhillon). | en_AU |
| dc.identifier.issn | 2234-943X | en_AU |
| dc.identifier.uri | http://hdl.handle.net/1885/96164 | |
| dc.publisher | Frontiers | |
| dc.rights | © 2015 Pereira, Mariadason, Hannan and Dhillon. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | |
| dc.source | Frontiers in Oncology | |
| dc.subject | crc | |
| dc.subject | cancer stem cell | |
| dc.subject | epithelial–mesenchymal transition | |
| dc.subject | serrated | |
| dc.subject | subtypes | |
| dc.subject | tumor progression | |
| dc.title | Implications of epithelial–mesenchymal plasticity for heterogeneity in colorectal cancer | |
| dc.type | Journal article | |
| local.bibliographicCitation.issue | 13 | |
| local.bibliographicCitation.startpage | 13 | en_AU |
| local.contributor.affiliation | Hannan, R., John Curtin School of Medical Research, The Australian National University | en_AU |
| local.contributor.authoruid | u1000203 | en_AU |
| local.description.notes | At the time of publication the author Hannan was affiliated with Peter MacCallum Cancer Centre, Research, Melbourne Victoria, Australia | en_AU |
| local.identifier.absfor | 111201 - Cancer Cell Biology | |
| local.identifier.absseo | 920102 - Cancer and Related Disorders | |
| local.identifier.ariespublication | u3700390xPUB234 | |
| local.identifier.citationvolume | 5 | en_AU |
| local.identifier.doi | 10.3389/fonc.2015.00013 | en_AU |
| local.identifier.essn | 2234-943X | en_AU |
| local.identifier.scopusID | 2-s2.0-84923229776 | |
| local.identifier.thomsonID | 000359072700001 | |
| local.publisher.url | http://www.frontiersin.org/ | en_AU |
| local.type.status | Published Version | en_AU |