Implications of epithelial–mesenchymal plasticity for heterogeneity in colorectal cancer
Date
2015-02-02
Authors
Pereira, Lloyd
Mariadason, John M.
Hannan, Ross D.
Dhillon, Amardeep S.
Journal Title
Journal ISSN
Volume Title
Publisher
Frontiers
Abstract
Colorectal cancer (CRC) is a genetically heterogeneous disease that develops and progresses through several distinct pathways characterized by genomic instability. In recent years, it has emerged that inherent plasticity in some populations of CRC cells can contribute to heterogeneity in differentiation state, metastatic potential, therapeutic response, and disease relapse. Such plasticity is thought to arise through interactions between aberrant signaling events, including persistent activation of the APC/β-catenin and KRAS/BRAF/ERK pathways, and the tumor microenvironment. Here, we highlight key concepts and evidence relating to the role of epithelial-mesenchymal plasticity as a driver of CRC progression and stratification of the disease into distinct molecular and clinicopathological subsets.
Description
Keywords
crc, cancer stem cell, epithelial–mesenchymal transition, serrated, subtypes, tumor progression
Citation
Collections
Source
Frontiers in Oncology
Type
Journal article
Book Title
Entity type
Access Statement
License Rights
Restricted until
Downloads
File
Description