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A Novel Functional Epitope Formed by Domains 1 and 4 of the Human Common beta -Subunit Is Involved in Receptor Activation by Granulocyte Macrophage Colony-stimulating Factor and Interleukin 5*

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Date

2003

Authors

Murphy, James
Ford, Sally
Wiedemann, Ursula
Carr, Paul D
Ollis, David
Young, Ian

Journal Title

Journal ISSN

Volume Title

Publisher

American Society for Biochemistry and Molecular Biology Inc

Abstract

The receptors for human interleukins 3 and 5 and granulocyte macrophage colony-stimulating factor are composed of ligand-specific α-subunits and a common β-subunit (βc), the major signaling entity. The way in which βc interacts with ligands in the res

Description

Keywords

Keywords: Crystal structure; Interfaces (materials); Mutagenesis; Proliferation; Biochemistry; epitope; fibronectin; granulocyte macrophage colony stimulating factor; interleukin 3; interleukin 5; ligand; protein subunit; epitope; granulocyte macrophage colony stim

Citation

URI

http://hdl.handle.net/1885/74429

Collections

ANU Research Publications

Source

Journal of Biological Chemistry

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1074/jbc.M211664200

Restricted until

2037-12-31

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01_Murphy_A_Novel_Functional_Epitope_2003.pdf (314.73 KB)

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