The use of genomewide ENU mutagenesis screens to unravel complex mammalian traits: identifying genes that regulate organ-specific and systemic autoimmunity

dc.contributor.authorHoyne, Gerard
dc.contributor.authorGoodnow, Christopher
dc.date.accessioned2015-12-13T23:04:01Z
dc.date.issued2006
dc.date.updated2015-12-12T07:52:51Z
dc.description.abstractT-cell development is perhaps one of the best understood processes of mammalian cell differentiation, as many of the genes and pathways have been identified. By contrast, relatively little is known about the genes and pathways involved in immunological tolerance to self-antigens. Here, we describe the challenges associated with a genomewide screen designed at identifying new immune regulatory genes that uses a model of organ-specific autoimmunity leading to type 1 diabetes. The successful propagation and identification of the new gene variants will shed light on the various developmental checkpoints in lymphocyte development that are crucial for establishing tolerance to self-antigens.
dc.identifier.issn0105-2896
dc.identifier.urihttp://hdl.handle.net/1885/85178
dc.publisherMunksgaard International Publishers
dc.sourceImmunological Reviews
dc.subjectKeywords: ethylnitrosourea; lymphocyte antigen receptor; autoimmunity; cell maturation; correlation analysis; diagnostic value; gene deletion; gene identification; gene library; gene mapping; gene sequence; genetic screening; genetic susceptibility; genetic trait;
dc.titleThe use of genomewide ENU mutagenesis screens to unravel complex mammalian traits: identifying genes that regulate organ-specific and systemic autoimmunity
dc.typeJournal article
local.bibliographicCitation.lastpage39
local.bibliographicCitation.startpage27
local.contributor.affiliationHoyne, Gerard, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationGoodnow, Christopher, College of Medicine, Biology and Environment, ANU
local.contributor.authoremailu9710462@anu.edu.au
local.contributor.authoruidHoyne, Gerard, u4049538
local.contributor.authoruidGoodnow, Christopher, u9710462
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor110703 - Autoimmunity
local.identifier.ariespublicationMigratedxPub13432
local.identifier.citationvolume210
local.identifier.doi10.1111/j.0105-2896.2006.00363.x
local.identifier.scopusID2-s2.0-33645288567
local.identifier.uidSubmittedByMigrated
local.type.statusPublished Version

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