Follow-up of mild cognitive impairment and related disorders over 4 years in adults in their sixties: The PATH Through Life Study

dc.contributor.authorCherbuin, Nicolas
dc.contributor.authorChristensen, Helen
dc.contributor.authorMeslin, Chantal
dc.contributor.authorSalim, Agus
dc.contributor.authorKumar, Rajeev
dc.contributor.authorJorm, Anthony F
dc.contributor.authorSachdev, Perminder Singh
dc.contributor.authorBurns, Richard
dc.contributor.authorAnstey, Kaarin
dc.date.accessioned2015-12-08T22:48:10Z
dc.date.available2015-12-08T22:48:10Z
dc.date.issued2008
dc.date.updated2015-12-08T11:03:56Z
dc.description.abstractAims: The study aimed to estimate incidence rates of mild cognitive impairment and related disorders, and conversion to dementia. Methods: The data are drawn from the PATH Through Life Study. Baseline assessment in 2001-2002 included 2,551 participants 60-64 years old with 2,222 participating in a 4-year follow-up. Those screened positive with a cognitive assessment received clinical assessment for diagnoses of mild cognitive disorders (MCD) or dementia using established clinical criteria. Prevalence and incidence rates for the cohort were estimated with predictive regression models. Results: Annual incidence of dementia was 0.25%. Prevalence of mild cognitive impairment was 4.2%, age-associated memory impairment was 2.4%, age-associated cognitive decline was 7.6%, mild neurocognitive disorders occurred in 12.9% and other cognitive disorders in 7.3%. Prevalence of any diagnosis of any MCD (Any-MCD) was 29.5% and the annual incidence rate for Any-MCD was 5.7%. Agreement for specific diagnoses between waves 1 and 2 was fair to poor (0-47.0%), but agreement for Any-MCD over 4 years was 89.0%. Conclusion: MCD diagnoses do not predict dementia at a 4-year follow-up in young-old adults. Prevalence rates for MCD vary greatly depending on the criteria and time of assessment.
dc.identifier.issn1420-8008
dc.identifier.urihttp://hdl.handle.net/1885/38227
dc.publisherS Karger AG
dc.sourceDementia and Geriatric Cognitive Disorders
dc.subjectKeywords: adult; article; clinical assessment; cognitive defect; controlled study; dementia; female; follow up; human; incidence; major clinical study; male; memory disorder; mini mental state examination; prevalence; priority journal; regression analysis; screenin Cognition disorders; Cognitive decline; Cognitive tests; Early diagnosis; Epidemiology; Longitudinal assessment; Mild cognitive impairment
dc.titleFollow-up of mild cognitive impairment and related disorders over 4 years in adults in their sixties: The PATH Through Life Study
dc.typeJournal article
local.bibliographicCitation.issue3
local.bibliographicCitation.lastpage233
local.bibliographicCitation.startpage226
local.contributor.affiliationAnstey, Kaarin, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationCherbuin, Nicolas, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationChristensen, Helen, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBurns, Richard, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMeslin, Chantal, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationSalim, Agus, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationKumar, Rajeev, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationJorm, Anthony F, University of Melbourne
local.contributor.affiliationSachdev, Perminder Singh, University of New South Wales (Prince of Wales Hospital)
local.contributor.authoremailu4038535@anu.edu.au
local.contributor.authoruidAnstey, Kaarin, u4038535
local.contributor.authoruidCherbuin, Nicolas, u3184049
local.contributor.authoruidChristensen, Helen, u8804902
local.contributor.authoruidBurns, Richard, u4009270
local.contributor.authoruidMeslin, Chantal, u4028155
local.contributor.authoruidSalim, Agus, u4163010
local.contributor.authoruidKumar, Rajeev, u3923137
local.description.notesImported from ARIES
local.identifier.absfor111714 - Mental Health
local.identifier.absfor110308 - Geriatrics and Gerontology
local.identifier.absseo920112 - Neurodegenerative Disorders Related to Ageing
local.identifier.ariespublicationU4146231xPUB159
local.identifier.citationvolume26
local.identifier.doi10.1159/000154646
local.identifier.scopusID2-s2.0-51249123516
local.identifier.thomsonID000259876400006
local.identifier.uidSubmittedByU4146231
local.type.statusPublished Version

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