Follow-up of mild cognitive impairment and related disorders over 4 years in adults in their sixties: The PATH Through Life Study
Date
2008
Authors
Cherbuin, Nicolas
Christensen, Helen
Meslin, Chantal
Salim, Agus
Kumar, Rajeev
Jorm, Anthony F
Sachdev, Perminder Singh
Burns, Richard
Anstey, Kaarin
Journal Title
Journal ISSN
Volume Title
Publisher
S Karger AG
Abstract
Aims: The study aimed to estimate incidence rates of mild cognitive impairment and related disorders, and conversion to dementia. Methods: The data are drawn from the PATH Through Life Study. Baseline assessment in 2001-2002 included 2,551 participants 60-64 years old with 2,222 participating in a 4-year follow-up. Those screened positive with a cognitive assessment received clinical assessment for diagnoses of mild cognitive disorders (MCD) or dementia using established clinical criteria. Prevalence and incidence rates for the cohort were estimated with predictive regression models. Results: Annual incidence of dementia was 0.25%. Prevalence of mild cognitive impairment was 4.2%, age-associated memory impairment was 2.4%, age-associated cognitive decline was 7.6%, mild neurocognitive disorders occurred in 12.9% and other cognitive disorders in 7.3%. Prevalence of any diagnosis of any MCD (Any-MCD) was 29.5% and the annual incidence rate for Any-MCD was 5.7%. Agreement for specific diagnoses between waves 1 and 2 was fair to poor (0-47.0%), but agreement for Any-MCD over 4 years was 89.0%. Conclusion: MCD diagnoses do not predict dementia at a 4-year follow-up in young-old adults. Prevalence rates for MCD vary greatly depending on the criteria and time of assessment.
Description
Keywords
Keywords: adult; article; clinical assessment; cognitive defect; controlled study; dementia; female; follow up; human; incidence; major clinical study; male; memory disorder; mini mental state examination; prevalence; priority journal; regression analysis; screenin Cognition disorders; Cognitive decline; Cognitive tests; Early diagnosis; Epidemiology; Longitudinal assessment; Mild cognitive impairment
Citation
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Source
Dementia and Geriatric Cognitive Disorders
Type
Journal article