The enigmatic genome of Chara australis virus

dc.contributor.authorGibbs, Adrian
dc.contributor.authorTorronen, Marjolein
dc.contributor.authorMackenzie, Anne
dc.contributor.authorWood, Jeffrey
dc.contributor.authorArmstrong, John
dc.contributor.authorKondo, Hideki
dc.contributor.authorTamada, Tetsuo
dc.contributor.authorKeese, Paul
dc.date.accessioned2015-12-10T23:13:23Z
dc.date.issued2011
dc.date.updated2016-02-24T12:09:35Z
dc.description.abstractMost of the genomic sequence of Chara australis virus (CAV), previously called Chara corallina virus, has been determined. It is a ssRNA molecule of 9065 nt with at least four ORFs. At its 59 end is an ORF encoding a protein of 227 kDa, distantly homologous to the multifunctional replicases of benyviruses and rubiviruses. Next is an ORF encoding a protein of 44 kDa, homologous to the helicases of pestiviruses. The third ORF encodes an unmatched protein of 38 kDa that is probably a movement protein. The fourth and 39-terminal ORF encodes a protein of 17.7 kDa homologous to the coat proteins of tobamoviruses. The short methyltransferase region of the CAV replicase matches only the C-terminal motif of benyvirus methyltransferases. This and other clues indicate that approximately 11% and 2% of the 59 and 39 termini of the complete CAV genome, respectively, are missing from the sequence. The aligned amino acid sequences of the CAV proteins and their nearest homologues contain many gaps but relationships inferred from them were little affected by removal of these gaps. Sequence comparisons show that three of the CAV genes may have diverged from the most closely related genes of other viruses 250-450 million years ago, and the sister relationship between the genes of CAV and those of benyviruses and tobamoviruses, mirroring the ancient sister relationship between charophytes (i.e. the algal host of CAV) and embryophytes (i.e. the plant hosts of tobamoviruses and benyviruses), is congruent with this possibility.
dc.identifier.issn0022-1317
dc.identifier.urihttp://hdl.handle.net/1885/64400
dc.publisherSociety for General Microbiology
dc.sourceJournal of General Virology
dc.subjectKeywords: coat protein; helicase; methyltransferase; orf 10 protein; orf 2 protein; orf 7 protein; orf 8 protein; unclassified drug; virus protein; amino acid sequence; article; chara australis; gene sequence; genetic analysis; nonhuman; nucleotide sequence; Pestiv
dc.titleThe enigmatic genome of Chara australis virus
dc.typeJournal article
local.bibliographicCitation.issue11
local.bibliographicCitation.lastpage2690
local.bibliographicCitation.startpage2679
local.contributor.affiliationGibbs, Adrian, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationTorronen, Marjolein, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMackenzie, Anne, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationWood, Jeffrey, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationArmstrong, John, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationKondo, Hideki, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationTamada, Tetsuo, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationKeese, Paul, College of Medicine, Biology and Environment, ANU
local.contributor.authoremailu4039956@anu.edu.au
local.contributor.authoruidGibbs, Adrian, u3037936
local.contributor.authoruidTorronen, Marjolein, u6500045
local.contributor.authoruidMackenzie, Anne, u7600632
local.contributor.authoruidWood, Jeffrey, u4039956
local.contributor.authoruidArmstrong, John, u4049870
local.contributor.authoruidKondo, Hideki, t1438
local.contributor.authoruidTamada, Tetsuo, t1436
local.contributor.authoruidKeese, Paul, t1437
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor060407 - Genome Structure and Regulation
local.identifier.absseo970106 - Expanding Knowledge in the Biological Sciences
local.identifier.ariespublicationu9511635xPUB930
local.identifier.citationvolume92
local.identifier.doi10.1099/vir.0.033852-0
local.identifier.scopusID2-s2.0-80053980893
local.identifier.thomsonID000296952300024
local.identifier.uidSubmittedByu9511635
local.type.statusPublished Version

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