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Activation of cathepsin D by glycosaminoglycans

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dc.contributor.authorBeckman, Marieen_AU
dc.contributor.authorFreeman, Craigen_AU
dc.contributor.authorSmall, David Hen_AU
dc.contributor.authorParish, Christopheren_AU
dc.date.accessioned2015-12-08T22:30:30Z
dc.date.issued2009
dc.date.updated2016-02-24T11:37:38Z
dc.description.abstractWe have previously shown that heparin can increase the activity of the proenzyme form of Alzheimer's β-site amyloid precursor protein cleaving enzyme 1 (BACE1). Cathepsin D (CD) is a member of the aspartic protease family and has sequence similarity to B
dc.identifier.issn1742-464X
dc.identifier.urihttp://hdl.handle.net/1885/34484
dc.publisherBlackwell Publishing Ltd
dc.sourceThe FEBS Journal
dc.subjectKeywords: amino acid; cathepsin D; enzyme precursor; glycosaminoglycan; heparin; procathepsin d; sulfate; unclassified drug; amino acid sequence; article; catalysis; controlled study; drug potency; enzyme activation; enzyme active site; enzyme activity; enzyme regu Aspartic protease; Cathepsin D; Glycosaminoglycan; Heparin; Proteolytic activity
dc.titleActivation of cathepsin D by glycosaminoglycans
dc.typeJournal article
local.bibliographicCitation.lastpage7352
local.bibliographicCitation.startpage7343
local.contributor.affiliationBeckman, Marie, Monash University
local.contributor.affiliationFreeman, Craig, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationParish, Christopher, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationSmall, David H, University of Tasmania
local.contributor.authoruidFreeman, Craig, u9113554
local.contributor.authoruidParish, Christopher, u6900322
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor110102 - Medical Biochemistry: Carbohydrates
local.identifier.ariespublicationu6800332xPUB113
local.identifier.citationvolume276
local.identifier.doi10.1111/j.1742-4658.2009.07444.x
local.identifier.scopusID2-s2.0-71949093178
local.identifier.thomsonID000272172600013
local.type.statusPublished Version

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