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Activation of cathepsin D by glycosaminoglycans

Date

Authors

Beckman, Marie

Freeman, Craig

Small, David H

Parish, Christopher

Publisher

Blackwell Publishing Ltd

Abstract

We have previously shown that heparin can increase the activity of the proenzyme form of Alzheimer's β-site amyloid precursor protein cleaving enzyme 1 (BACE1). Cathepsin D (CD) is a member of the aspartic protease family and has sequence similarity to B

Keywords

Keywords: amino acid; cathepsin D; enzyme precursor; glycosaminoglycan; heparin; procathepsin d; sulfate; unclassified drug; amino acid sequence; article; catalysis; controlled study; drug potency; enzyme activation; enzyme active site; enzyme activity; enzyme regu Aspartic protease; Cathepsin D; Glycosaminoglycan; Heparin; Proteolytic activity

URI

http://hdl.handle.net/1885/34484

Collections

ANU Research Publications

Source

The FEBS Journal

Type

Journal article

DOI

10.1111/j.1742-4658.2009.07444.x

Restricted until

2037-12-31

Downloads

File

Description

01_Beckman_Activation_of_cathepsin_D_by_2009.pdf (308.79 KB)

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