Hepatosplenic T-cell lymphoma, immunosuppressive agentsand biologicals: what are the risks?

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dc.contributor.authorSubramaniam, Kavitha
dc.contributor.authorYeung, D.
dc.contributor.authorGrimpen, F.
dc.contributor.authorJoseph, J.
dc.contributor.authorFay, K.
dc.contributor.authorBuckland, M.
dc.contributor.authorTalaulikar, Dipti
dc.contributor.authorElijah, J.
dc.contributor.authorClarke, A. C.
dc.contributor.authorPavli, Paul
dc.contributor.authorMoore, J.
dc.date.accessioned2015-12-08T22:18:27Z
dc.date.issued2014
dc.date.updated2015-12-08T08:16:29Z
dc.description.abstractWe present three cases of the rare hepatosplenic T-cell lymphoma (HSTCL); two patients suffering from Crohn disease who developed HSTCL on azathioprine without exposure to biologicals, and a third patient who had psoriasis treated using etanercept, cyclosporine and methotrexate. The evidence for an association between HSTCL and immunosuppressive drugs and biologicals is reviewed. We argue for improved pharmacovigilance processes to help determine the benefit to risk ratios for the use of these and other new agents.
dc.identifier.issn1444-0903
dc.identifier.urihttp://hdl.handle.net/1885/31354
dc.publisherBlackwell Science Asia
dc.sourceInternal Medicine Journal
dc.titleHepatosplenic T-cell lymphoma, immunosuppressive agentsand biologicals: what are the risks?
dc.typeJournal article
local.bibliographicCitation.issue3
local.bibliographicCitation.lastpage290
local.bibliographicCitation.startpage287
local.contributor.affiliationSubramaniam, Kavitha, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationYeung, D., Department of Haematology and UNSW Clinical Scho
local.contributor.affiliationGrimpen, F., Gastroenterology and Hepatology Unit
local.contributor.affiliationJoseph, J., Department of Haematology and UNSW Clinical School
local.contributor.affiliationFay, K., Department of Haematology
local.contributor.affiliationBuckland, M., Department of Anatomical Pathology
local.contributor.affiliationTalaulikar, Dipti, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationElijah, J., Office of Medicines Safety Monitoring
local.contributor.affiliationClarke, A.C., Gastroenterology and Hepatology Unit
local.contributor.affiliationPavli, Paul, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMoore, J., Department of Haematology and UNSW Clinical School
local.contributor.authoruidSubramaniam, Kavitha, u5430653
local.contributor.authoruidTalaulikar, Dipti, u4283279
local.contributor.authoruidPavli, Paul, u3683784
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor110202 - Haematology
local.identifier.ariespublicationu4425841xPUB82
local.identifier.citationvolume44
local.identifier.doi10.1111/imj.12363
local.identifier.scopusID2-s2.0-84896849512
local.identifier.thomsonID000332641300012
local.type.statusPublished Version

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