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Hepatosplenic T-cell lymphoma, immunosuppressive agentsand biologicals: what are the risks?

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Date

2014

Authors

Subramaniam, Kavitha
Yeung, D.
Grimpen, F.
Joseph, J.
Fay, K.
Buckland, M.
Talaulikar, Dipti
Elijah, J.
Clarke, A. C.
Pavli, Paul

Journal Title

Journal ISSN

Volume Title

Publisher

Blackwell Science Asia

Abstract

We present three cases of the rare hepatosplenic T-cell lymphoma (HSTCL); two patients suffering from Crohn disease who developed HSTCL on azathioprine without exposure to biologicals, and a third patient who had psoriasis treated using etanercept, cyclosporine and methotrexate. The evidence for an association between HSTCL and immunosuppressive drugs and biologicals is reviewed. We argue for improved pharmacovigilance processes to help determine the benefit to risk ratios for the use of these and other new agents.

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Keywords

Citation

URI

http://hdl.handle.net/1885/31354

Collections

ANU Research Publications

Source

Internal Medicine Journal

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1111/imj.12363

Restricted until

2037-12-31

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