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Role of T cell costimulation in anti-viral immunity

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dc.contributor.authorBertram, Edward
dc.contributor.authorDawicki, Wojcieck
dc.contributor.authorWatts, Tania H.
dc.date.accessioned2015-12-13T22:41:01Z
dc.date.available2015-12-13T22:41:01Z
dc.date.issued2004
dc.date.updated2015-12-11T09:58:45Z
dc.description.abstractMembers of both the CD28 and TNFR families can have costimulatory roles in T cell activation. Gene targeted mice as well as in vivo blocking experiments have established distinct roles for CD28/B7; ICOS/ICOSL; CD27/CD70; 4-1BB/4-1BBL and OX40/OX40L during viral infection. Many issues remain to be addressed, including the timing and location of the interactions, the possibility of partial redundancy between related family members and the molecular basis for the specific phenotypes observed in the different gene targeted mice.
dc.identifier.issn1044-5323
dc.identifier.urihttp://hdl.handle.net/1885/78310
dc.publisherAcademic Press
dc.sourceSeminars in Immunology
dc.subjectKeywords: B7 antigen; CD134 antigen; CD137 antigen; CD27 antigen; CD28 antigen; CD4 antigen; CD40 antigen; CD40 ligand; CD70 antigen; immunoglobulin M; inducible costimulator protein; interleukin 2; major histocompatibility antigen class 1; protein; T lymphocyte re CD28 family; Costimulation; DLN; draining lymph node; T cells; thymidine kinase; TIM; TK; TNF receptor associated factor; TNFR; TNFR family; TRAF; TRAF interacting motif; tumor necrosis factor receptor; Viruses
dc.titleRole of T cell costimulation in anti-viral immunity
dc.typeJournal article
local.bibliographicCitation.issue3
local.bibliographicCitation.lastpage196
local.bibliographicCitation.startpage185
local.contributor.affiliationBertram, Edward, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationDawicki, Wojcieck, University of Toronto
local.contributor.affiliationWatts, Tania H., University of Toronto
local.contributor.authoruidBertram, Edward, u4056697
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor110704 - Cellular Immunology
local.identifier.ariespublicationMigratedxPub6977
local.identifier.citationvolume16
local.identifier.doi10.1016/j.smim.2004.02.006
local.identifier.scopusID2-s2.0-2342631978
local.type.statusPublished Version

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