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Role of T cell costimulation in anti-viral immunity

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Date

2004

Authors

Bertram, Edward
Dawicki, Wojcieck
Watts, Tania H.

Journal Title

Journal ISSN

Volume Title

Publisher

Academic Press

Abstract

Members of both the CD28 and TNFR families can have costimulatory roles in T cell activation. Gene targeted mice as well as in vivo blocking experiments have established distinct roles for CD28/B7; ICOS/ICOSL; CD27/CD70; 4-1BB/4-1BBL and OX40/OX40L during viral infection. Many issues remain to be addressed, including the timing and location of the interactions, the possibility of partial redundancy between related family members and the molecular basis for the specific phenotypes observed in the different gene targeted mice.

Description

Keywords

Keywords: B7 antigen; CD134 antigen; CD137 antigen; CD27 antigen; CD28 antigen; CD4 antigen; CD40 antigen; CD40 ligand; CD70 antigen; immunoglobulin M; inducible costimulator protein; interleukin 2; major histocompatibility antigen class 1; protein; T lymphocyte re CD28 family; Costimulation; DLN; draining lymph node; T cells; thymidine kinase; TIM; TK; TNF receptor associated factor; TNFR; TNFR family; TRAF; TRAF interacting motif; tumor necrosis factor receptor; Viruses

Citation

URI

http://hdl.handle.net/1885/78310

Collections

ANU Research Publications

Source

Seminars in Immunology

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1016/j.smim.2004.02.006

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