Ring Flexibility within Tricyclic Antidepressant Drugs

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dc.contributor.authorCasarotto, Marco
dc.contributor.authorCraik, David J
dc.date.accessioned2015-12-13T23:26:31Z
dc.date.issued2001
dc.date.updated2015-12-12T09:46:50Z
dc.description.abstractThe internal flexibility of the central seven-membered ring of a series of tricyclic antidepressant drugs (TCAs), imipramine {1}, amitriptyline{2}, doxepin {3}, and dothiepin {4}, has been investigated by 1H and 13C nuclear magnetic (NMR) techniques. Two
dc.identifier.issn0022-3549
dc.identifier.urihttp://hdl.handle.net/1885/92864
dc.publisherJohn Wiley & Sons Inc
dc.sourceJournal of Pharmaceutical Sciences
dc.subjectKeywords: amitriptyline; chloride; dosulepin; doxepin; imipramine; tricyclic antidepressant agent; anxiety neurosis; article; carbon nuclear magnetic resonance; drug mechanism; drug potency; drug receptor binding; drug structure; molecular dynamics; proton nuclear Molecular dynamics; NMR; Relaxation measurements; Ring inversion
dc.titleRing Flexibility within Tricyclic Antidepressant Drugs
dc.typeJournal article
local.bibliographicCitation.issue6
local.bibliographicCitation.lastpage721
local.bibliographicCitation.startpage713
local.contributor.affiliationCasarotto, Marco, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationCraik, David J, University of Queensland
local.contributor.authoremailu9611346@anu.edu.au
local.contributor.authoruidCasarotto, Marco, u9611346
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor111502 - Clinical Pharmacology and Therapeutics
local.identifier.ariespublicationMigratedxPub26108
local.identifier.citationvolume90
local.identifier.doi10.1002/jps.1027
local.identifier.scopusID2-s2.0-0034986792
local.identifier.uidSubmittedByMigrated
local.type.statusPublished Version

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