Ring Flexibility within Tricyclic Antidepressant Drugs

Date

Authors

Casarotto, Marco

Craik, David J

Publisher

John Wiley & Sons Inc

Abstract

The internal flexibility of the central seven-membered ring of a series of tricyclic antidepressant drugs (TCAs), imipramine {1}, amitriptyline{2}, doxepin {3}, and dothiepin {4}, has been investigated by 1H and 13C nuclear magnetic (NMR) techniques. Two

Keywords

Keywords: amitriptyline; chloride; dosulepin; doxepin; imipramine; tricyclic antidepressant agent; anxiety neurosis; article; carbon nuclear magnetic resonance; drug mechanism; drug potency; drug receptor binding; drug structure; molecular dynamics; proton nuclear Molecular dynamics; NMR; Relaxation measurements; Ring inversion

URI

http://hdl.handle.net/1885/92864

Collections

ANU Research Publications

Source

Journal of Pharmaceutical Sciences

Type

Journal article

DOI

10.1002/jps.1027

Restricted until

2037-12-31

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Description

01_Casarotto_Ring_Flexibility_within_2001.pdf (203.44 KB)