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The total synthesis of (−)-tetrahydrolipstatin (Short Communication)

Date

Authors

Bodkin, Jennifer A

Humphries, Edward

McLeod, Malcolm

Publisher

Elsevier

Abstract

Careful control during the bromolactonisation of β,γ-unsaturated acid 3 was required to afford regioselectively the trans-β-lactone 4 as the major diastereomer. Radical debromination of 4 followed by a three-step sequence of reactions afforded the lipa

Keywords

Keywords: acid; lactone derivative; tetrahydrolipstatin; article; bromolactonization; chemical reaction; debromination; diastereoisomer; drug synthesis; proton nuclear magnetic resonance; stereochemistry ß-lactone; (-)-tetrahydrolipstatin; Bromolactonisation; Radical dehalogenation

URI

http://hdl.handle.net/1885/56725

Collections

ANU Research Publications

Source

Tetrahedron Letters

Type

Journal article

DOI

10.1016/S0040-4039(03)00443-X

Restricted until

2037-12-31

Downloads

File

Description

01_Bodkin_The_total_synthesis_of_2003.pdf (190.9 KB)