The fumagillin biosynthetic gene cluster in Aspergillus fumigatus encodes a cryptic terpene cyclase involved in the formation of -trans-bergamotene
Date
2013
Authors
Lin, Hsiao-Ching
Chooi, Yit-Heng
Dhingra, Sourabh
Xu, Wei
Calvo, Ana M
Tang, Yi
Journal Title
Journal ISSN
Volume Title
Publisher
American Chemical Society
Abstract
Fumagillin 1 is a meroterpenoid from Aspergillus fumigatus that is known for its anti-angiogenic activity by binding to human methionine aminopeptidase 2. The genetic and molecular basis for biosynthesis of 1 had been an enigma despite the availability of
Description
Keywords
Keywords: Acyltransferase; Anti-angiogenic activity; Aspergillus fumigatus; Biosynthetic gene cluster; Genome sequences; Methionine aminopeptidase; Molecular basis; Polyketide synthases; Amino acids; Aspergillus; Biochemistry; Biosynthesis; Plants (botany); Terpene
Citation
Collections
Source
Journal of the American Chemical Society
Type
Journal article
Book Title
Entity type
Access Statement
License Rights
Restricted until
2037-12-31
Downloads
File
Description