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Germinal Center Lymphocyte Ratios and Successful HIV Vaccines

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Date

2017

Authors

Gonzalez-Figueroa, Paula
Roco, Jonathan
Vinuesa, Carola

Journal Title

Journal ISSN

Volume Title

Publisher

Elsevier

Abstract

Current HIV vaccines are poor inducers of neutralizing antibodies (nAbs). A recent study in Cell Reports used serial fine-needle aspirates from rhesus macaque lymph nodes following HIV-1 surface envelope glycoprotein (Env) trimer immunization, generating a substantial production of HIV-1 nAbs. A remarkable correlation was found between antibody titers and a high frequency and ratio of germinal center B and T follicular helper (TFH) lymphocytes.

Description

Keywords

Citation

URI

http://hdl.handle.net/1885/238327

Collections

ANU Research Publications

Source

Trends in Molecular Medicine

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1016/1.molmed.2016.12.009

Restricted until

2099-12-31

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