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Implications of epithelial–mesenchymal plasticity for heterogeneity in colorectal cancer

Pereira, Lloyd; Mariadason, John M.; Hannan, Ross D.; Dhillon, Amardeep S.


Colorectal cancer (CRC) is a genetically heterogeneous disease that develops and progresses through several distinct pathways characterized by genomic instability. In recent years, it has emerged that inherent plasticity in some populations of CRC cells can contribute to heterogeneity in differentiation state, metastatic potential, therapeutic response, and disease relapse. Such plasticity is thought to arise through interactions between aberrant signaling events, including persistent...[Show more]

CollectionsANU Research Publications
Date published: 2015-02-02
Type: Journal article
Source: Frontiers in Oncology
DOI: 10.3389/fonc.2015.00013


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