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Islet β cell failure in type 2 diabetes

Prentki, M.; Nolan, C.

Description

The major focus of this Review is on the mechanisms of islet beta cell failure in the pathogenesis of obesity-associated type 2 diabetes (T2D). As this demise occurs within the context of beta cell compensation for insulin resistance, consideration is also given to the mechanisms involved in the compensation process, including mechanisms for expansion of beta cell mass and for enhanced beta cell performance. The importance of genetic, intrauterine, and environmental factors in the determination...[Show more]

dc.contributor.authorPrentki, M.
dc.contributor.authorNolan, C.
dc.date.accessioned2016-01-20T05:39:38Z
dc.date.available2016-01-20T05:39:38Z
dc.identifier.issn0021-9738
dc.identifier.urihttp://hdl.handle.net/1885/95533
dc.description.abstractThe major focus of this Review is on the mechanisms of islet beta cell failure in the pathogenesis of obesity-associated type 2 diabetes (T2D). As this demise occurs within the context of beta cell compensation for insulin resistance, consideration is also given to the mechanisms involved in the compensation process, including mechanisms for expansion of beta cell mass and for enhanced beta cell performance. The importance of genetic, intrauterine, and environmental factors in the determination of "susceptible" islets and overall risk for T2D is reviewed. The likely mechanisms of beta cell failure are discussed within the two broad categories: those with initiation and those with progression roles.
dc.description.sponsorshipThis work was supported by grants from Genome Quebec, Canada, the NIH (DK-63356), the Canadian Institute of Health Research, and the Private Practice Fund of The Canberra Hospital, Australian Capital Territory, Australia
dc.publisherAmerican Society for Clinical Investigation
dc.rightsCopyright © 2006, The American Society for Clinical Investigation. http://www.sherpa.ac.uk/romeo/issn/0021-9738..."author can archive publisher's version/PDF. Authors personal websites, institutional repositories and funding-body repositories" from SHERPA/RoMEO site (as at 20/01/16).
dc.sourceJournal of Clinical Investigation
dc.subjectanimals
dc.subjectdiabetes mellitus, type 2
dc.subjectdisease progression
dc.subjectgenetic predisposition to disease
dc.subjecthumans
dc.subjectinsulin resistance
dc.subjectinsulin-secreting cells
dc.titleIslet β cell failure in type 2 diabetes
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume116
dc.date.issued2006-07-03
local.identifier.absfor110306
local.identifier.ariespublicationu4133361xPUB283
local.publisher.urlhttps://www.the-asci.org/index.shtml/
local.type.statusPublished Version
local.contributor.affiliationPrentki, Marc, University of Montreal, Canada
local.contributor.affiliationNolan, Christopher, College of Medicine, Biology and Environment, CMBE ANU Medical School, ANU Medical School, The Australian National University
local.bibliographicCitation.issue7
local.bibliographicCitation.startpage1802
local.bibliographicCitation.lastpage1812
local.identifier.doi10.1172/JCI29103
dc.date.updated2016-02-24T10:36:42Z
local.identifier.scopusID2-s2.0-33745863033
CollectionsANU Research Publications

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