Islet β cell failure in type 2 diabetes

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dc.contributor.authorPrentki, M.
dc.contributor.authorNolan, C.
dc.date.accessioned2016-01-20T05:39:38Z
dc.date.available2016-01-20T05:39:38Z
dc.date.issued2006-07-03
dc.date.updated2016-02-24T10:36:42Z
dc.description.abstractThe major focus of this Review is on the mechanisms of islet beta cell failure in the pathogenesis of obesity-associated type 2 diabetes (T2D). As this demise occurs within the context of beta cell compensation for insulin resistance, consideration is also given to the mechanisms involved in the compensation process, including mechanisms for expansion of beta cell mass and for enhanced beta cell performance. The importance of genetic, intrauterine, and environmental factors in the determination of "susceptible" islets and overall risk for T2D is reviewed. The likely mechanisms of beta cell failure are discussed within the two broad categories: those with initiation and those with progression roles.
dc.description.sponsorshipThis work was supported by grants from Genome Quebec, Canada, the NIH (DK-63356), the Canadian Institute of Health Research, and the Private Practice Fund of The Canberra Hospital, Australian Capital Territory, Australiaen_AU
dc.identifier.issn0021-9738en_AU
dc.identifier.urihttp://hdl.handle.net/1885/95533
dc.publisherAmerican Society for Clinical Investigation
dc.rightsCopyright © 2006, The American Society for Clinical Investigation. http://www.sherpa.ac.uk/romeo/issn/0021-9738..."author can archive publisher's version/PDF. Authors personal websites, institutional repositories and funding-body repositories" from SHERPA/RoMEO site (as at 20/01/16).
dc.sourceJournal of Clinical Investigation
dc.subjectanimals
dc.subjectdiabetes mellitus, type 2
dc.subjectdisease progression
dc.subjectgenetic predisposition to disease
dc.subjecthumans
dc.subjectinsulin resistance
dc.subjectinsulin-secreting cells
dc.titleIslet β cell failure in type 2 diabetes
dc.typeJournal article
local.bibliographicCitation.issue7en_AU
local.bibliographicCitation.lastpage1812en_AU
local.bibliographicCitation.startpage1802en_AU
local.contributor.affiliationPrentki, Marc, University of Montreal, Canadaen_AU
local.contributor.affiliationNolan, Christopher, College of Medicine, Biology and Environment, CMBE ANU Medical School, ANU Medical School, The Australian National Universityen_AU
local.contributor.authoremailchristopher.nolan@anu.edu.auen_AU
local.contributor.authoruidu1820721en_AU
local.description.notesImported from ARIESen_AU
local.identifier.absfor110306en_AU
local.identifier.ariespublicationu4133361xPUB283en_AU
local.identifier.citationvolume116en_AU
local.identifier.doi10.1172/JCI29103en_AU
local.identifier.scopusID2-s2.0-33745863033
local.identifier.uidSubmittedByu3488905en_AU
local.publisher.urlhttps://www.the-asci.org/index.shtml/en_AU
local.type.statusPublished Versionen_AU

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