Ring Flexibility within Tricyclic Antidepressant Drugs
Date
2001
Authors
Casarotto, Marco
Craik, David J
Journal Title
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Volume Title
Publisher
John Wiley & Sons Inc
Abstract
The internal flexibility of the central seven-membered ring of a series of tricyclic antidepressant drugs (TCAs), imipramine {1}, amitriptyline{2}, doxepin {3}, and dothiepin {4}, has been investigated by 1H and 13C nuclear magnetic (NMR) techniques. Two
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Keywords
Keywords: amitriptyline; chloride; dosulepin; doxepin; imipramine; tricyclic antidepressant agent; anxiety neurosis; article; carbon nuclear magnetic resonance; drug mechanism; drug potency; drug receptor binding; drug structure; molecular dynamics; proton nuclear Molecular dynamics; NMR; Relaxation measurements; Ring inversion
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Source
Journal of Pharmaceutical Sciences
Type
Journal article
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2037-12-31
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