A new model of sheep Ig diversification: shifting the emphasis toward combinatorial mechanisms and away from hypermutation
Date
2003
Authors
Jenne, C
Kennedy, L
McCullagh, Peter
Reynolds, J
Journal Title
Journal ISSN
Volume Title
Publisher
American Association of Immunologists
Abstract
The current model of Ig repertoire development in sheep focuses on the rearrangement of a small number (∼20) of Vλ gene segments. It is believed that this limited combinatorial repertoire is then further diversified through postrearrangement somatic hy
Description
Keywords
Keywords: immunoglobulin; animal cell; animal tissue; article; combinatorial chemistry; controlled study; gene mutation; gene rearrangement; genetic variability; nonhuman; nucleotide sequence; priority journal; sheep; somatic hypermutation; Aging; Amino Acid Sequen
Citation
Collections
Source
Journal of Immunology
Type
Journal article